Tissue microarrays are produced by re-locating tissues from
conventional histological blocks. Typically, 40 to 1,000
cylindrical formalin-fixed and paraffin-embedded tissue cores can
be densely and precisely arrayed into a single paraffin block. From
the block, up to 300 serial 4-8 μm thick sections can be
produced and placed on individual glass microscopic slides. Tissue
microarray enables parallel in situ detection of DNA, RNA, or
protein targets in each specimen on an array at cellular and tissue
levels; at the same time, the large number of available consecutive
arrays allows rapid analysis of multiple molecular markers in the
same set of specimens. Essentially the same tests performed on
conventional histological samples including H&E staining,
immunohistochemistry and in situ hybridization can be done
separately, or in parallel, on tissue microarrays.
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