Williamwhite Essay Writing

Tissue microarrays are produced by re-locating tissues from conventional histological blocks. Typically, 40 to 1,000 cylindrical formalin-fixed and paraffin-embedded tissue cores can be densely and precisely arrayed into a single paraffin block. From the block, up to 300 serial 4-8 μm thick sections can be produced and placed on individual glass microscopic slides. Tissue microarray enables parallel in situ detection of DNA, RNA, or protein targets in each specimen on an array at cellular and tissue levels; at the same time, the large number of available consecutive arrays allows rapid analysis of multiple molecular markers in the same set of specimens. Essentially the same tests performed on conventional histological samples including H&E staining, immunohistochemistry and in situ hybridization can be done separately, or in parallel, on tissue microarrays.