Amid the ongoing COVID-19 coronavirus pandemic, influenza virus
remains a major threat to public health due to its potential to
cause seasonal and cyclical pandemics with significant morbidity
worldwide and mortality. According to the World Health Organization
(WHO), seasonal influenza affects 5-10% of the global population
each year, resulting in 3-5 million hospitalizations and
approximately 500,000 deaths.
Types of
Influenza Virus Vaccine Development Service
Influenza virus belongs to the Orthomyxoviridae family and comprise
negative-sense, single stranded, segmented RNA genome. Influenza
virus causes acute upper respiratory tract infection in patients
and spreads rapidly through the air, causing periodic influenza
pandemics around the world. There are four types of influenza
viruses: A, B, C, and D. Influenza A virus (IAV) and B virus are
clinically relevant to humans. IAVs can be further subdivided into
18 hemagglutinin (HA) and 11 neuraminidase (NA) subtypes based on
the antigenic properties of surface glycoproteins. Most IAV
subtypes exist in natural hosts (e.g., waterfowl, waterfowl, and
other species), and only a few IAV subtypes infect humans. Because
of the high mutation rate, IAV is difficult to predict, prevent or
treat.
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