Secondary Structure Analysis
Reported by creativebiostructure | January 25th, 2024 @ 06:03 AM
The secondary structure of proteins describes strands or
stretches with unique characteristic local structural conformations
based on hydrogen bonds. The two main types of protein secondary
structures are α-helix and β-sheet. The α-helix is a
right-handed strand in which the side chain of the amino acid
sequence extends laterally. Hydrogen bonds are responsible for the
structural stability of proteins. The hydrogen bond in a
β-sheet fit between the strands (inter-strand). The sheet
conformation is composed of pairs of strands lying side by side.
The carbonyl oxygens in one strand interact with the amino
hydrogens of the adjacent strand.
Creative Biostructure provides several services for investigating
protein secondary structure. Quantifying the secondary structure
components such as α-helix, β-sheet, bends, and turns has
been used to better understand the higher-order structure (HOS)
product quality attributes of the protein under study and utilized
to support stability studies, formulation development, process
development, and comparability studies
Featured Secondary Structure Analysis Services
Circular Dichroism (CD) Spectroscopy Serviceg>
CD spectroscopy is a technique that has been widely applied in
structural biology for examining the secondary structure, tertiary
structure, conformational changes, as well as folding and binding
interactions involving protein molecules. The CD spectrum arises
from an electronically symmetrical chromophore in an asymmetric
environment. The chromophores that absorb light in the UV range are
the peptide backbone and the aromatic amino acids and disulfide
bonds. The result is electromagnetic interactions between
neighboring chromophores that can be detected
spectroscopically.
No comments found
Please Sign in or create a free account to add a new ticket.
With your very own profile, you can contribute to projects, track your activity, watch tickets, receive and update tickets through your email and much more.
Create your profile
Help contribute to this project by taking a few moments to create your personal profile. Create your profile ยป