Circular RNA (circRNA)
is emerging as a new class of endogenous and regulatory noncoding
RNA in recent years. Generally, most circRNAs function as miRNA
sponges or transcription/translation regulator to impact the
expression of miRNA target genes, which plays important roles in
the regulation of cancers. With the widespread application of RNA
sequencing (RNA-seq) technology and bioinformatics prediction,
large numbers of circRNAs have been identified. However, low
abundance expression level of circRNA significantly limits the
detection efficiency of RNA-seq. Therefore, high-throughput
microarray may act as a more sensitive, efficient and
cost-effective technology for circRNA expression profiling.
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