dopaminergic neurons
Reported by cailynn johnson | February 23rd, 2024 @ 08:43 AM
At the onset of symptoms, putamen dopamine is depleted 80%, and 60% of SNpc dopaminergic neurons have already been lost. However, the cell bodies of mesolimbic dopaminergic neurons adjacent to SNpc are affected to a limited extent in PD. Consequently, there is significantly less depletion of dopamine in the caudate. Thus, the selective loss of dopamine in the striatum primarily contributes to PD pathology.
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cailynn johnson